Year: 2015
Type: dissertation
Abstract: Electrical and metabolic activities of the heart are closely connected, however, the dynamics of this relationship remains unclear. In this thesis, the relationship between the electrophysiology and metabolism of the heart is studied. Using mouse heart in Langendorff set-up and an optical system to measure NADH and calcium concurrently in endocardium of the mouse heart, the effect of heart rate on metabolism is studied. Based on the experimental measurements, a mathematical model of metabolism and electrophysiology of the heart is constructed and used for exploring new drug therapeutic strategies.
Source: TSpace (University of Toronto)
Author: Farrokh Mansouri
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2569336013