Year: 2017
Type: article
Abstract: The adenoviral early region 1A gene (E1A) is a modulator of cellular and viral gene transcription and the primary mediator of cell cycle induction during infection of quiescent cells. It is through these cell cycle effects that E1A can immortalize cells during either abortive infection or stable expression. A side effect of E1A altering cell cycle and host transcriptional activity is that expression of E1A increases the sensitivity of cells to cytotoxicity induced by components of the host cellular immune response (natural killer cells, cytotoxic T cells and macrophages) and apoptosis-inducing injuries (TNF-super family members, chemotherapeutic agents and oxidative stress). 1 As a result of cell sensitizing E1A activities, targeted expression and delivery of E1A to tumor cells has been used to treat various forms of cancer. However, the cellular pathways and mechanisms through which E1A increases cellular sensitivity to these potentially cytotoxic injuries are not well defined.
Source: Cell Death and Disease
Authors: Jay R Radke, James L Cook
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,990
OpenAlex ID: W2569932744