Work

T cell exhaustion: from pathophysiological basics to tumor immunotherapy

Year: 2017

Type: review

Abstract: The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoimmunity and immunopathology. One of the mechanisms that have evolved to prevent destruction by the immune system, is to functionally silence effector T cells, termed T cell exhaustion, which is also exploited by viruses and cancers for immune escape In this review, we discuss some of the phenotypic markers associated with T cell exhaustion and we summarize current strategies to reinvigorate exhausted T cells by blocking these surface marker using monoclonal antibodies.

Source: Cell Communication and Signaling

DOI: 10.1186/s12964-016-0160-z

Authors: Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger

Institutions: Paracelsus Medical University, Labor für Immunologische und Molekulare Krebsforschung

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390