Work

miR-125b promotes MLL-AF9–driven murine acute myeloid leukemia involving a VEGFA-mediated non–cell-intrinsic mechanism

Year: 2017

Type: article

Abstract: Key Points miR-125b overexpression accelerates MLL-AF9–driven AML and endows partial addiction to its overexpression. A miR-125b-TET2-VEGFA pathway promotes leukemogenesis involving a non–cell-intrinsic mechanism.

Source: Blood

DOI: 10.1182/blood-2016-06-721027

Authors: Jun Liu, Bo Guo, Zhuo Chen, Nayi Wang, Michelina Iacovino, Jijun Cheng, Christine Roden, Wen Pan, Sajid Khan, Suning Chen, Michael Kyba, Rong Fan, Shangqin Guo, Jun Lu

Institutions: Yale Cancer Center, Yale University, Chinese People's Liberation Army, First Affiliated Hospital of Soochow University, University of Minnesota

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Yale University, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Molecular definition of cancer cell-of-origin, G3922867758, G4462060839, The role of microRNAs in leukemic initiation and maintenance, Genetics and Genomics of Human Disease

OpenAlex ID: W2570849516

FWCI: 3.763

Cites: 62

Cited by: 50

Related to: 10