Work

Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology

Year: 2017

Type: review

Abstract: Networks of redox sensor proteins within discrete microdomains regulate the flow of redox signaling. Yet, the inherent reactivity of redox signals complicates the study of specific redox events and pathways by traditional methods. Herein, we review designer chemistries capable of measuring flux and/or mimicking subcellular redox signaling at the cellular and organismal level. Such efforts have begun to decipher the logic underlying organelle-, site-, and target-specific redox signaling in vitro and in vivo. These data highlight chemical biology as a perfect gateway to interrogate how nature choreographs subcellular redox chemistry to drive precision redox biology.

Source: ACS Chemical Biology

DOI: 10.1021/acschembio.6b01148

Authors: Marcus J. C. Long, Jesse R. Poganik, Souradyuti Ghosh, Yimon Aye

Institutions: Cornell University, Weill Cornell Medicine

Language: Hebrew

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green