Year: 2017
Type: review
Abstract: Lung cancer is the deadliest cancer in the United States, killing roughly one of four cancer patients in 2016. While it is well-established that lung cancer is caused primarily by environmental effects (particularly tobacco smoking), there is evidence for genetic susceptibility. Lung cancer has been shown to aggregate in families, and segregation analyses have hypothesized a major susceptibility locus for the disease. Genetic association studies have provided strong evidence for common risk variants of small-to-moderate effect. Rare and highly penetrant alleles have been identified by linkage studies, including on 6q23-25. Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease.
Source: Genes
DOI: 10.3390/genes8010036
Institutions: National Institutes of Health, National Human Genome Research Institute, University of Tennessee Health Science Center, Mayo Clinic, Louisiana State University Health Sciences Center New Orleans, University of Toledo, Dartmouth College, Medical College of Wisconsin, Medical College of Wisconsin Cancer Center, Wayne State University, The Barbara Ann Karmanos Cancer Institute, University of Cincinnati
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,137
OpenAlex ID: W2571743590