Work

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining T reg and antitumor CTL function

Year: 2017

Type: article

Abstract: Inhibiting Aurora kinase A and JAK2 signal transduction pathways permits the differentiation of potent regulatory T cells while neutralizing alloreactive T cells and preventing graft-versus-host disease without impairing antitumor responses.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aai8269

Authors: Brian C. Betts, Anandharaman Veerapathran, Joseph Pidala, Hua Yang, Pedro Horna, Kelly Walton, Christopher L. Cubitt, Steven Gunawan, Harshani R. Lawrence, Nicholas J. Lawrence, Said M. Sebti, Claudio Anasetti

Institutions: University of South Florida, Moffitt Cancer Center

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: JAK2_STAT3 as a therapeutic target and marker of graft-versus-host disease, G6639194018, Moffitt Cancer Center Support Grant, Targeting T-cell costimulation and cytokine activation to prevent GVHD and preserve GVL

OpenAlex ID: W2572018381

FWCI: 3.102

Cites: 46

Cited by: 50

Related to: 10