Efficacy of nebivolol‐valsartan single‐pill combination in obese and nonobese patients with hypertension
Year: 2017
Type: article
Abstract: Antihypertensive efficacy of single‐pill combinations (SPCs) consisting of a β1‐selective adrenergic blocker with vasodilatory properties via β3‐agonism (nebivolol) and an angiotensin II receptor blocker (valsartan) was demonstrated in an 8‐week phase 3 trial (NCT01508026). In this post hoc analysis, seated blood pressure, heart rate, 24‐hour ambulatory blood pressure monitoring, plasma aldosterone, estimated glomerular filtration rate, and safety measures were assessed in obese (body mass index >32 kg/m2; n=1823) and nonobese (body mass index <27 kg/m2; n=847) adults with hypertension (stage I or II) treated with nebivolol‐valsartan SPCs, nebivolol or valsartan monotherapy, or placebo. At week 8, reductions from baseline in blood pressure and ambulatory blood pressure monitoring were greater with SPCs and most nebivolol and valsartan monotherapy doses vs placebo regardless of obesity status. Aldosterone declined with all active treatments and estimated glomerular filtration rate remained steady. The nebivolol‐valsartan 5/80 mg/d SPC was efficacious regardless of degree of obesity.
Source: Journal of Clinical Hypertension
DOI: 10.1111/jch.12965
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
OpenAlex ID: W2574638270