Work

Ring-shaped confocal photoacoustic computed tomography for small-animal whole-body imaging

Year: 2012

Type: conference-paper

Abstract: We report herein a novel three-dimensional photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The PACT system, based on a 512-element full-ring ultrasonic transducer array, was cylindrically focused and capable of forming a two-dimensional image in 1.6 seconds. The pulsed laser could either illuminate directly from the top or be reshaped to illuminate the sample from the side. Top illumination was mainly used for mouse brain and mouse embryo imaging. Side illumination provided in vivo anatomical images of an adult mouse. By translating the mouse along the elevational direction, the system provided serial cross-sectional images.

Source: Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI: 10.1117/12.906056

Authors: Jun Xia, Muhammad Chatni, Konstantin Maslov, Zijian Guo, Mark Anastasio, Lihong V. Wang

Institution: Washington University in St. Louis

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering