Work

Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen’s Amine

Year: 2017

Type: article

Abstract: We report an enantioselective coupling between α-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters. The choice of Rh and organocatalyst combination allows for access to all possible stereoisomers with high enantio-, diastereo-, and regioselectivity. Our study highlights the power of catalysis to activate two common functional groups and provide access to divergent stereoisomers and constitutional structures.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.6b10680

Authors: Faben A. Cruz, Vy M. Dong

Institution: University of California, Irvine

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, Eli Lilly and Company, University of California, Irvine, National Institute of General Medical Sciences

Awards: G4285699969, G5041083365