Work

Identification of chaperones in a MPP+-induced and ATRA/TPA-differentiated SH-SY5Y cell PD model.

Year: 2016

Type: article

Abstract: treatment with SH-SY5Y cells. However, the NPM1 protein was identified for the first time in the PD model. The upregulation of four chaperone proteins provided evidence that these chaperones have a complementary effect on protein misfolding in the pathogenesis of PD, and hold promise as a good therapeutic target for PD treatment.

Source: PubMed Central

Authors: Hongrong Xie, Hui Hu, Ming Chang, Dongya Huang, Xiaobo Gu, Xinli Xiong, Ran Xiong, Linsen Hu, Gang Li

Institutions: Tongji University, Shanghai East Hospital, First Hospital of Jilin University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2575646686

FWCI: 0.498

Cites: 63

Cited by: 15

Related to: 10