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A Prospective Study of Altered Inflammatory Response and Its Clinical Outcome following Laparoscopic and Open Cholecystectomy.

Year: 2017

Type: article

Abstract: BACKGROUND: Inflammatory response following surgical trauma has long been a matter of study. Results, however, have been varied. We sought to assess changes in the levels of proinflammatory and anti-inflammatory cytokines in patients undergoing laparoscopic and open cholecystectomy and their impact on the clinical outcome of patients concerning the postoperative pain score. METHODS: -test was used to compare the means of a variable between the 2 groups. Statistical analysis was done using SPSS, version 17. RESULTS: postoperative hour, the patients in the laparoscopic cholecystectomy group had a significantly lower pain score (P<0.001) than the open group. CONCLUSION: Both laparoscopic and open cholecystectomy procedures altered the inflammatory milieu of our patients in the postoperative period. Inflammation caused by the laparoscopic procedure was significantly less. More research is needed to target specific inflammatory and anti-inflammatory cytokines to reduce surgical stress and improve patient outcomes.

Source: PubMed

Authors: Sayyed Ehtesham Hussain Naqvi, Atia Zaka-Ur-Rab, Najmul Islam, Eram Ali

Institution: Aligarh Muslim University

Language: English

Topic: Minimally Invasive Surgical Techniques

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2576767119

FWCI: 0.837

Cites: 16

Cited by: 8

Related to: 10