Work

Germ cell tumors: Insights from the Drosophila ovary and the mouse testis

Year: 2017

Type: review

Abstract: Ovarian and testicular germ cell tumors of young adults are thought to arise from defects in germ cell development, but the molecular mechanisms underlying malignant transformation are poorly understood. In this review, we focus on the biology of germ cell tumor formation in the Drosophila ovary and the mouse testis, for which evidence supports common underlying mechanisms, such as blocking initiation into the differentiation pathway, impaired lineage progression, and sexual identity instability. We then discuss how these concepts inform our understanding of the disease in humans. Mol. Reprod. Dev. 84: 200-211, 2017. © 2017 Wiley Periodicals, Inc.

Source: Molecular Reproduction and Development

DOI: 10.1002/mrd.22779

Authors: Helen K. Salz, Emily P. Dawson, Jason D. Heaney

Institutions: Case Western Reserve University, Baylor College of Medicine

Language: English

Topic: Testicular diseases and treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Institute of General Medical Sciences