The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data
Year: 2017
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: The presence of biofilms in chronic non-healing wounds, has been identified through in vitro model and in vivo animal data. However, human chronic wound studies are under-represented and generally report low sample sizes. For this reason we sought to ascertain the prevalence of biofilms in human chronic wounds by undertaking a systematic review and meta-analysis. Our initial search identified 554 studies from the literature databases (Cochrane Library, Embase, Medline). After removal of duplicates, and those not meeting the requirements of inclusion, nine studies involving 185 chronic wounds met the inclusion criteria. Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI 61.6-89, p<0.002]). The results of our meta-analysis support our clinical assumptions that biofilms are ubiquitous in human chronic non-healing wounds.
Source: Journal of Wound Care
Institutions: Liverpool Hospital, Ingham Institute, South Western Sydney Local Health District, University of Copenhagen, Rigshospitalet, University of Manchester, Montana State University, The Ohio State University, University of Huddersfield, Imperial College London, Tohoku University, University of Florida, Southwest Regional Wound Care Center
Language: English
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2579236691