Work

The TGF-β Family inCaenorhabditis elegans

Year: 2017

Type: preprint

Abstract: Transforming growth factor b (TGF-b) and related ligands have potent effects on an enormous diversity of biological functions in all animals examined.Because of the strong conservation of TGF-b family ligand functions and signaling mechanisms, studies from multiple animal systems have yielded complementary and synergistic insights.In the nematode Caenorhabditis elegans, early studies were instrumental in the elucidation of TGF-b family signaling mechanisms.Current studies in C. elegans continue to identify new functions for the TGF-b family in this organism as well as new conserved mechanisms of regulation.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a022178

Authors: Cathy Savage-Dunn, Richard W. Padgett

Institutions: Queens College, CUNY, The Graduate Center, CUNY, Rutgers, The State University of New Jersey, Rutgers Cancer Institute

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institute for Health and Care Research, National Institutes of Health, National Institute of General Medical Sciences

Awards: Genetics of Cell Signaling in C. elegans Growth Regulation, Intercellular Signaling and Endosome to Golgi Transport in Multicellular Animals, Regulation of Metabolism by C. elegans DBL-1/BMP Signaling