Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry
Year: 2017
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA). METHODS: Retrospective cohort study of 1118 patients, who underwent coronary CTA at two centers from September 2004 to October 2011. Coronary CTA were categorized as normal, nonobstructive CAD (<50%), or obstructive CAD (≥50%) in addition to segment involvement (SIS) and stenosis scores. Extensive CAD was defined as SIS > 4. Association of BMI with cardiovascular prognosis was evaluated using multivariable fractional polynomial models. RESULTS: , after adjustment for age, gender, and smoking, MetS (HR 2.23, p = 0.009) was more strongly associated with adverse events. CONCLUSIONS: . Within each BMI category, metabolically unhealthy patients had greater extent of CAD, as measured by CCTA, compared to metabolically healthy patients.
Source: Cardiovascular Diabetology
Institutions: Brigham and Women's Hospital, Harvard University, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Universidade de São Paulo, Hospital Universitário da Universidade de São Paulo, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, The University of Texas Southwestern Medical Center, Baptist Health South Florida, Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,290
OpenAlex ID: W2580086929