Transporter and Metabolic-based Drug-Drug Interactions: The Blood-Brain Barrier and The Liver
Year: 2013
Type: dissertation
Abstract: The HIV Protease inhibitor (PI)-based DDIs are complex, unpredictable and often paradoxical.Investigations dedicated to evaluating PIs' potential as inducers of the CYPs and drug transporter, and PIs' as substrates of hepatic uptake transporters haven been scarce, especially those using human hepatocytes, an advanced in vitro systems that provides the most comprehensive and in vivo-like hepatocyte cellular characteristics.These investigations are much needed to better understand and predict the in vivo DDIs with PIs as precipitant and/or object drugs.Therefore, we used human hepatocytes and performed 1) comprehensive quantification of the net induction potential of the eight PIs for nine major hepatic CYPs
Author: Li Liu
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2580960287