Year: 2017
Type: preprint
Study design: Observational Study
Abstract: Interferons and defensins are antimicrobial peptides that can also induce anti-tumor immunity. By analyzing the copy number profiles of 10,759 patients across 31 cancer types, we found the homozygous deletions of interferon and defensin genes are prevailing in most human cancers, and that patients with these homozygous deletions exhibited significant reduced overall survival or disease-free survival. We further demonstrated that the homozygous deletion of interferon and defensin genes significantly impacted the expression of genes regulated by tumor necrosis factor (TNF) and IFNγ. Our findings suggested a novel immune escape mechanism that disrupts the tumor cells’ ability to be recognized, and have implications for personalized immunotherapy.
DOI: 10.1101/101741
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2581343724