Work

Single-shot edge illumination x-ray phase-contrast tomography enabled by joint image reconstruction

Year: 2017

Type: article

Abstract: Edge illumination x-ray phase-contrast tomography (EIXPCT) is an emerging x-ray phase-contrast tomography technique for reconstructing the complex-valued x-ray refractive index distribution of an object. Conventional image reconstruction approaches for EIXPCT require multiple images to be acquired at each tomographic view angle. This contributes to prolonged data-acquisition times and elevated radiation doses, which can hinder in vivo applications. In this work, a new "single-shot" method is proposed for joint reconstruction (JR) of the real and imaginary-valued components of the refractive index distribution from a tomographic data set that contains only a single image acquired at each view angle. The proposed method is predicated on a nonlinear formulation of the inverse problem that is solved by using a gradient-based optimization method. The method is validated and investigated using computer-simulated and experimental EIXPCT data sets.

Source: Optics Letters

DOI: 10.1364/ol.42.000619

Authors: Yujia Chen, Huifeng Guan, Charlotte K. Hagen, Alessandro Olivo, Mark A. Anastasio

Institutions: Washington University in St. Louis, University College London

Language: English

Topic: Advanced X-ray Imaging Techniques

Subfield: Radiation

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, Engineering and Physical Sciences Research Council, National Institute of Biomedical Imaging and Bioengineering

Awards: An Enabling Technology for Preclinical X-Ray Imaging of Biomaterials In-Vivo, Collaborative Research: Development of Preclinical X-Ray Phase Contrast Tomography for 3D Imaging of Engineered Tissues, G4137480266, Transforming the use of x-rays in science and society, G8073483692