Year: 2005
Type: article
Abstract: Obesity is a chronic disease of multifactorial origin arising from a long-term energy imbalance, in which both genetic and environmental factors may be involved.Obesity is an important cause of morbidity and mortality in developed countries.Implementation of effective strategies in prevention and management of obesity should become a major target in the health care systems worldwide.Weight loss and maintenance depend on the interaction of genetic, metabolic, psychobehavioral and environmental factors.Responsiveness to weight reduction programmes shows a wide interindividual variation and reliable weight loss predictors have not been available.Major advances have been made recently in the study of genetics of obesity with more than 400 candidate obesity genes being characterized.This paper summarizes available data on the involvement of hereditary factors in weight loss and maintenance.Twin and family studies demonstrated that the weight loss is strongly controlled by genotype.Polymorphisms in several obesity candidate genes was shown to influence the outcome of weight management.However, several studies yield ambiguous results.It should considered that the eating behaviour as a major predictor of weight loss maintenance is also significantly genetically determined.Weight loss achieved in response to obesity treatment might also be influenced by changes in obesogenic and/or leptogenic genes expression induced by environmental factors such as the type of ingested nutrient and level of physical activity.Hereditary factors and weight loss Supported by grant IGA NR/7800-4 from the Ministry of Health, Czech Republic Endokrynologia, Otyłość i Zaburzenia Przemiany Materii 2005, tom 1, nr 1, s. 1-8More comprehensive studies on interaction between candidate obesity genes, psychobehavioral factors and environmental factors are needed for better understanding the outcome of weight management in our increasingly obesogenic environment.
Source: Via Medica Journals
Author: Vojtěch Hainer
Institution: Institute of Endocrinology
Language: Polish
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2581917785