Synthesis and Cytotoxicity Assessment of Gold-coated Magnetic Iron Oxide Nanoparticles.
Year: 2018
Type: article
Abstract: INTRODUCTION: One class of magnetic nanoparticles is magnetic iron oxide nanoparticles (MIONs) which has been widely offered due to of their many advantages. Owing to the extensive application of MIONs in biomedicine, before they can be used in vivo, their cytotoxicity have to be investigated. Therefore, there is an urgent need for understanding the potential risks associated with MIONs. MATERIALS AND METHODS: nanoparticles (GMNP) were synthesized. The size, structure and spectroscopic properties of the nanoparticles were characterized by transmission electron microscopy (TEM), X-ray diffractometry (XRD) and UV-Visible spectrophotometer, respectively. Cytotoxicity of nanoparticles was studied with different concentrations ranging from 10 µg/mL up to 400 µg/mL and for different incubation times (12 hours and 24 hours) on MCF-7 and HFFF-PI6. Cytotoxicity study was performed by MTT assay. RESULTS: nanoparticles have higher cytotoxicity than GMNPs. CONCLUSION: ions in intracellular space. Moreover, cell toxicity increased with raise in dose (concentration) and incubation time.
Source: Europe PMC (PubMed Central)
Authors: M Keshtkar, D Shahbazi-Gahrouei, M A Mehrgardi, M Aghaei, S M Khoshfetrat
Institutions: Isfahan University of Medical Sciences, University of Isfahan
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2582413035