Compositional Analysis of Homogeneous Regions in Human Genomic DNA
Year: 2002
Type: article
Abstract: Due to increased production of human DNA sequence, it is now possible to explore and understand human genomic organization at the sequence level. In particular, we have studied one of the major organizational components of vertebrate genome organization previously described as isochores (Bernardi, 1993), which are compositionally homogeneous DNA segments based on G+C content. We have examined sequence data for the existence of compositionally differing regions and report that while compositionally homogeneous regions are present in the human genome, current isochore classification schemes are too brad for sequence-level data.
DOI: 10.7936/k7gm85pv
Author: Rouchka, Eric C.
Institution: Washington University in St. Louis
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2582552577