Surg-07a Multi-institutional Experience on Laser Thermal Ablation as Treatment for Corpus Callosal Glioblasotmas
Year: 2015
Type: article
Abstract: INTRODUCTION: Surgical management of glioblastomas involving the corpus callosum is of particular challenge. Accordingly, patients afflicted with this disease entity exhibit poor survival relative to other forms of glioblastomas. The development of minimally invasive, stereotactic laser thermal ablation now offers a new surgical option against this disease. METHODS: We present a multi-institutional experience (Cleveland Clinic, University of California San Diego, University Hospital-Case Medical Center) in the treatment of glioblastoma that involve the corpus callosum. Radiographic control, peri-operative morbidities, time of hospitalization, and overall survival were examined. RESULTS: All 16 patients harbored histologically confirmed diagnosis of glioblastoma. Five patients were newly diagnosed and underwent ablation before TMZ/RT while the remaining 10 patients were treated after TMZ/RT failure. The median age of the cohort is 52 (range: 29-68), with a median KPS of 80 (range 60-100). Three patients suffered transient post-operative hemiparesis. The average length of hospital stay was 3.3 days (range: 1-11 days). 13 of the 16 patients underwent subsequent chemotherapy treatment. No tumor growth was observed within the region of thermal ablation in any of the treated patient. The median survival of the cohort has not been reached. Eleven of the treated patients (69%) survived > 3 months – the reported median survival for corpus callosal glioblastoma patients without surgical resection. The overall survival for these 11 patients ranged 5 to 35 months. CONCLUSIONS: Glioblastoma involving the corpus callosum can be safely treated through laser thermal ablation. Our multi-institutional experience provides evidence in support of safety and suggest potential efficacy in select patients.
Source: Neuro-Oncology
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2583693911