Year: 2017
Type: preprint
Abstract: The ability of structure-based design to control the shape and reactivity-the atomic-level chemistry-of an immunogen argues for it being one of the "most powerful" immunogendesign strategies.But antigenic reactivity is only one of the properties required to induce a protective immune response.Here, a multidimensional approach is used to exemplify the enabling role atomic-level information can play in the development of immunogens against three viral pathogens, respiratory syncytial virus, influenza A virus, and human immunodeficiency virus (HIV), which have resisted standard approaches to vaccine development.Overall, structure-based strategies incorporating B-cell ontogenies and viral evasion mechanisms appear exceptionally powerful. GREAT DEBATESWhat are the most interesting topics likely to come up over dinner or drinks with your colleagues?Or, more importantly, what are the topics that don't come up because they are a little too controversial?In Immune Memory and Vaccines: Great Debates, Editors Rafi Ahmed and Shane Crotty have put together a collection of articles on such questions, written by thought leaders in these fields, with the freedom to talk about the issues as they see fit.This short, innovative format aims to bring a fresh perspective by encouraging authors to be opinionated, focus on what is most interesting and current, and avoid restating introductory material covered in many other reviews.The Editors posed 13 interesting questions critical for our understanding of vaccines and immune memory to a broad group of experts in the field.In each case, several different perspectives are provided.Note that while each author knew that there were additional scientists addressing the same question, they did not know who these authors were, which ensured the independence of the opinions and perspectives expressed in each article.Our hope is that readers enjoy these articles and that they trigger many more conversations on these important topics.
Author: Peter D. Kwong
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2583710135