Work

Decreased Hippocampal Volume is Related to White Matter Abnormalities in Treatment-Resistant Depression

Year: 2013

Type: article

Abstract: Despite considerable research on the pathophysiology of unipolar depression, relationships between gray and white matter brain changes associated with treatment-resistant depression (TRD) have been sparsely investigated. Here, we used voxel-based morphometry and tract-based spatial statistics to examine differences in fronto-limbic gray matter volume and their connecting white matter tracts, respectively. We compared a well-characterized group of medication-free TRD patients (n = 22), who had homogenous treatment backgrounds consisting of standardized psychotherapeutic treatment and a combination of antidepressants and mood stabilizers, to matched healthy controls (n = 21).

Source: International Journal of Brain Disorders and Treatment

DOI: 10.23937/2469-5866/1510012

Author: Christina B Young

Institutions: Northwestern University, Radboud University Nijmegen, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour

Language: English

Topic: Treatment of Major Depression

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2584570932