Work

Regulation of protein metabolism in cancer

Year: 2017

Type: editorial

Abstract: Our recent studies determined molecular interactions between genes in the ubiquitin-proteasome pathways and cancer cell metabolism. Ubiquitin-specific peptidase 13 (USP13) specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase that drive ovarian cancer metabolism. These findings may lead to the development of USP13 inhibitors and new-targeted therapies in ovarian cancers.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2017.1285384

Authors: Cecil Han, Xiongbin Lu, Deepak Nagrath

Institutions: The University of Texas MD Anderson Cancer Center, University of Michigan

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health