Work

Erratum: Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC.

Year: 2017

Type: article

Abstract: . We first demonstrated the upregulation of colonic PDE-5 expression and the prevention role of PDE-5 inhibition in AOM/DSS-induced tumorigenesis model. More importantly, PDE-5 inhibitor Sildenafil inhibited colonic tumorigenesis dependent on inflammation and suppressed DSS-induced colitis. Molecular mechanism investigation indicated that Sildenafil regulated inflammation microenvironment via directly inhibiting MDSC infiltration in colonic tissue. The study provides solid evidence for the use of PDE-5 inhibitor in preventing and treating colonic inflammation-related tumorigenesis.

Source: Europe PMC (PubMed Central)

Authors: Shiyong Lin, Jing Wang, Lihui Wang, Jing Wen, Yandong Guo, Weiguang Qiao, Jieqiong Zhou, Guoliang Xu, Fachao Zhi

Institutions: Nanfang Hospital, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Southern Medical University

Language: English

Topic: Phosphodiesterase function and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2584899489

FWCI: 4.066

Cites: 34

Cited by: 82

Related to: 10