Year: 2017
Type: article
Abstract: Methylation of N 6 adenosine (m 6 A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the development of human cancers is poorly understood. By analyzing datasets from the Cancer Genome Atlas Research Network (TCGA) acute myeloid leukemia (AML) study, we discover that mutations and/or copy number variations of m 6 A regulatory genes are strongly associated with the presence of TP53 mutations in AML patients. Further, our analyses reveal that alterations in m 6 A regulatory genes confer a worse survival in AML. Our work indicates that genetic alterations of m 6 A regulatory genes may cooperate with TP53 and/or its regulator/downstream targets in the pathogenesis and/or maintenance of AML.
Source: Journal of Hematology & Oncology
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,990
Awards: Investigating the role of aberrant splicing (intron retention) in acute myeloid leukaemia, Deciphering the role of intron retention in monocyte differentiation and function, Intron retention regulation in granulopoiesis and leukaemia, Investigating widespread regulation of gene expression through intron retention
OpenAlex ID: W2584920615