Immunological consequences of strain variation within the Mycobacterium tuberculosis complex
Year: 2017
Type: article
Abstract: In 2015, there were an estimated 10.4 million new cases of tuberculosis (TB) globally, making it one of the leading causes of death due to an infectious disease. TB is caused by members of the Mycobacterium tuberculosis complex (MTBC), with human disease resulting from infection by M. tuberculosis sensu stricto and M. africanum. Recent progress in genotyping techniques, in particular the increasing availability of whole genome sequence data, has revealed previously under appreciated levels of genetic diversity within the MTBC. Several studies have shown that this genetic diversity may translate into differences in TB transmission, clinical manifestations of disease, and host immune responses. This suggests the existence of MTBC genotype-dependent host-pathogen interactions which may influence the outcome of infection and progression of disease. In this review, we highlight the studies demonstrating differences in innate and adaptive immunological outcomes consequent on MTBC genetic diversity, and discuss how these differences in immune response might influence the development of TB vaccines, diagnostics and new therapies.
Source: European Journal of Immunology
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,550
Awards: G1145983601, G1288721568, G2006052962, G2301282499, G2542180245, G2919344005, G3037950497, Host directed therapies against tuberculosis., G3967759381, G4791776336, From Genes to Disease: Investigating the Role Of ECM1 Variants in the Pathogenesis of Inflammatory Bowel Disease., Centre for Infectious Diseases Research in Africa (CIDRI-Africa), G5679603166, Host directed therapies against tuberculosis., G7364435899, G7574714948, G790109484, G8116470440, G8674496788, G9000011953, G9000068883, G9000152420
OpenAlex ID: W2585160258