Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
Year: 2017
Type: article
Study design: Observational Study
Abstract: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER–, n = 386), matched 1:1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The associations between OPG and ER+ and ER– breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER– breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24–3.02]; p trend = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER– disease did not differ by menopausal status at blood collection (p het = 0.97), and we observed no heterogeneity by HT use at blood collection (p het ≥ 0.43) or age at breast cancer diagnosis (p het ≥ 0.30). This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER– breast cancer.
Source: BMC Medicine
Authors: Renée T. Fortner, Danja Sarink, Helena Schock, Theron Johnson, Anne Tjønneland, Anja Olsen, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Philippos Orfanos, Domenico Palli, Sabina Sieri, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. Van Gils, Elisabete Weiderpass, Eiliv Lund, J. Ramón Quirós, Antonio Agudo, Maria-José Sánchez, María-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Tim Key, Kay-Tee Khaw, Sabina Rinaldi, Laure Dossus, Marc Gunter, Melissa A. Merritt, Elio Riboli, Rudolf Kaaks
Institutions: German Cancer Research Center, Danish Cancer Society, Aarhus University, Université Paris-Sud, Inserm, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Fondation Gustave Roussy, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Hellenic Health Foundation, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Federico II University Hospital, University of Naples Federico II, University of Turin, University of Malaya, National Institute for Public Health and the Environment, Imperial College London, University Medical Center Utrecht, MRC Centre for Environment and Health, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Gobierno del Principado de Asturias, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Biogipuzkoa Health Research Institute, University of Oxford, University of Cambridge, Centre international de recherche sur le cancer
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funders: World Health Organization, Universitetet i Tromsø, Kræftens Bekæmpelse, Deutsches Krebsforschungszentrum, Centre International de Recherche sur le Cancer, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, University of Oxford, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Karolinska Institutet, Ligue Contre le Cancer, Vetenskapsrådet, Universiti Malaya, Universidad de Murcia, NordForsk, Samfundet Folkhälsan, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Universidad de Granada, Università degli Studi di Torino, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, MRC-PHE Centre for Environment and Health, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, Seventh Framework Programme, Rijksinstituut voor Volksgezondheid en Milieu, School of Public Health, Imperial College London
Awards: G1032970344, G1055973116, G1074694216, G1075502044, G1090603134, G1192877484, G1208621354, G1241080153, G1265254713, G1274701479, G1318397260, G1344656563, G1478484880, G1532219801, G1559294051, G172151099, G1767199718, G1788645866, G1907752718, G1952936224, G1993546569, G2027148636, G2131326840, G2149779140, G2149865848, G2216207056, G2235605558, G2257231888, G2336049343, G2372467518, G2409987178, G2539064604, G2561548287, G2572521044, G2611591051, G2657122180, G2709920838, G273148272, G2742323354, G2841678936, G2871896171, G29072894, G2924980845, G2999139090, G3010599472, G3049845011, G3077395769, G3084320185, G3149246560, G3170664214, G3189789075, G3216658785, G331404038, G3350062835, G3452641779, G3461390129, G3544161537, G3568965380, G3675143906, G3747421453, G375319704, G3816092139, G382879149, G3980646122, G3998443608, G4012977212, G4015156572, G4041385912, G4049848471, G4081633361, G4089957676, G4201735853, G4213141252, G423622538, G4303038735, G43956866, The RANK-Axis in Breast Cancer: A comprehensive prospective evaluation of promising novel biomarkers, G4473162978, Health of vegetarians, G459595259, G4682079261, G4752739612, G4811780622, G4879533352, G4884057766, G490534113, G4913827001, G5004963360, G5047213743, G5119219000, G5375816427, G5406065712, G5456958854, G5560955959, G5578953934, G558017500, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5868006920, G5897142711, G5990830295, G6085534252, NIHR Senior Investigator Award, G6212483348, G6231161894, G6264211199, G6320156643, G640002926, G6442500046, G657255654, G6594529311, G6631454880, G6723261869, G6779186093, G6820515600, G6960682749, G7022277044, G7025202487, G7040807446, G7306252069, G7426181285, G7447125227, G7505152690, G7600088736, G7624991799, G7646326732, G7853538257, G7939399614, G8012318887, G8050896463, G817390530, G8279237360, G8331243404, G8374761964, G8407261631, G8500560359, G8508326818, G8525262851, G8697954213, G876765158, G8867963557, G8869854444, G8959392569, G8978728421, G9000332718
OpenAlex ID: W2585404175