Work

MicroRNA-101 inhibits proliferation, migration and invasion in osteosarcoma cells by targeting ROCK1.

Year: 2017

Type: article

Abstract: < 0.01). Moreover, knockdown of ROCK1 reversed the promotion effect of miR-101 knockdown on proliferation, migration, and invasion while promoted apoptosis of MG63 cells, suggesting that miR-101 acts as a tumor suppressor in osteosarcoma cells via targeting ROCK1. Furthermore, overexpression of miR-101 inhibited tumor growth and motion by inactivating PI3K/AKT and JAK/STAT signaling pathways via downregulation of ROCK1. To conclude, miR-101/ROCK1 may be a potential therapeutic target for osteosarcoma therapy.

Source: PubMed

Authors: Rui Jiang, Chao Zhang, Guangyao Liu, Rui Gu, Han Wu

Institutions: Jilin University, Second Affiliated Hospital of Jilin University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2585419016

FWCI: 3.237

Cites: 28

Cited by: 50

Related to: 10