Year: 2017
Type: review
Abstract: The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion, and a major site of host immunity. In order to keep up with daily demands, the intestine has evolved a mechanism to expand the absorptive surface area by undergoing a morphogenetic process to generate finger-like units called villi. These villi house specialized cell types critical for both absorbing nutrients from food, and for protecting the host from commensal and pathogenic microbes present in the adult gut. In this review, we will discuss mechanisms that coordinate intestinal development, growth, and maturation of the small intestine, starting from the formation of the early gut tube, through villus morphogenesis and into early postnatal life when the intestine must adapt to the acquisition of nutrients through food intake, and to interactions with microbes.
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,670
Funders: University of Cambridge, National Institutes of Health, University of California, San Francisco, Michigan Institute for Clinical and Health Research, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center, University of Michigan Center for Gastrointestinal Research, Engineered human intestinal organoids: a modular system to model enteric disease, Molecular Mechanisms of Microbial Pathogenesis Training Program, Michigan Institute for Clinical and Health Research (MCHR), G7958222963, Intestinal Stem Cell Consortium Coordinating Center, Niche support of human intestinal stem cells, Training in Basic and Translational Digestive Sciences
OpenAlex ID: W2585548548