P2–241: Plasma testosterone levels and cognitive function in borderline hypogonadal older men
Year: 2006
Type: article
Study design: Observational Study
Abstract: Testosterone (T) levels decrease with age in men. Low T has been associated with cognitive impairment. This study examines the association between T levels and cognitive function in borderline hypogonadal older men. Plasma levels of testosterone, lipids, and cognitive function was investigated in older men with low to slightly below normal serum T levels. We present preliminary data on 73 community–dwelling, older healthy men, with the emphasis on 22 individuals who completed cognitive and laboratory baseline testing. Their mean age is 67.6 ± 6.3 and T levels mean is 397 ± 150.7. Of these subjects, 5% presented a baseline total T level < 200 ng/dl, 40% between 200–350 ng/dl, and 55% > 350 ng/dl. Their mean BMI is 27 ± 3.7. A noteworthy characteristics of this cohort is the high level of education (90% have a college or higher degree). Of the men who completed cognitive screening, 36% scored positive for mild cognitive impairment (MCI) using the Short Test of Mental Status (STMS). This result supports the concept that cognitive function may be affected by testosterone levels. An important finding of this cohort is the high prevalence of MCI in highly educated borderline hypogonadal older men.
Source: Alzheimer s & Dementia
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2585981970