GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults
Year: 2020
Type: article
Abstract: Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that ‘for approved indications, GH is safe’; however, the statement highlighted a number of areas for on-going surveillance of long-term safety, including cancer risk, impact on glucose homeostasis, and use of high dose pharmacological rhGH treatment. Over the intervening years, there have been a number of publications addressing the safety of rhGH with regard to mortality, cancer and cardiovascular risk, and the need for long-term surveillance of the increasing number of adults who were treated with rhGH in childhood. Against this backdrop of interest in safety, the European Society of Paediatric Endocrinology (ESPE), the GRS, and the Pediatric Endocrine Society (PES) convened a meeting to reappraise the safety of rhGH. The ouput of the meeting is a concise position statement.
DOI: 10.17615/k2hj-9p61
Authors: Clemmons, D, Ho, K, Cianfarani, S, Johannsson, G, Erfurth, E M, Chihara, K, Kopchick, J, Burman, P, Cohen, P, Robison, L, Lee, P, Radovick, S, Backeljauw, P, Grimberg, A, Clayton, P, Butler, G, Hokken-Koelega, A, Boguszewski, M, Pollak, M, Christiansen, J, Rosenfeld, R, Bidlingmaier, M, Hoffman, A R, Deal, C, Allen, D B, Dunger, D, Haymond, M, Biller, B M K, Higham, C, Juul, A, Fuqua, J S, Darendeliler, F
Institutions: University of Wisconsin–Madison, Cincinnati Children's Hospital Medical Center, Ludwig-Maximilians-Universität München, Massachusetts General Hospital, Universidade Federal do Paraná, Lund University, University College London, Hyogo Prefectural Kakogawa Medical Center, Aarhus University, University of Rome Tor Vergata, Health Innovation Manchester, University of North Carolina at Chapel Hill, University of Southern California, Istanbul University, Université de Montréal, University of Cambridge, Indiana University Bloomington, University of Pennsylvania, Baylor College of Medicine, The Christie NHS Foundation Trust, Princess Alexandra Hospital, Stanford University, Erasmus University Rotterdam, University of Gothenburg, University of Copenhagen, Ohio University, Pennsylvania State University, McGill University, Johns Hopkins University, St. Jude Children's Research Hospital, Oregon Health & Science University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2586426312