Year: 2018
Type: article
Abstract: Family trees have vast applications in multiple fields from genetics to anthropology and economics. However, the collection of extended family trees is tedious and usually relies on resources with limited geographical scope and complex data usage restrictions. Here, we collected 86 million profiles from publicly-available online data from genealogy enthusiasts. After extensive cleaning and validation, we obtained population-scale family trees, including a single pedigree of 13 million individuals. We leveraged the data to partition the genetic architecture of longevity by inspecting millions of relative pairs and to provide insights to population genetics theories on the dispersion of families. We also report a simple digital procedure to overlay other datasets with our resource in order to empower studies with population-scale genealogical data. One Sentence Summary Using massive crowd-sourced genealogy data, we created a population-scale family tree resource for scientific studies.
Source: Science
Institutions: New York Genome Center, Whitehead Institute for Biomedical Research, Technion – Israel Institute of Technology, Weizmann Institute of Science, Harvard University, Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Broad Institute, Columbia University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Burroughs Wellcome Fund, Broad Institute, Israel Science Foundation, Syddansk Universitet, Scheme for Promotion of Academic and Research Collaboration, National Institutes of Health, National Institute of Mental Health, National Human Genome Research Institute, National Institute of General Medical Sciences
OpenAlex ID: W2951742207