Work

Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City

Year: 2017

Type: article

Abstract: ABSTRACT Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 bla KPC -harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and K . michiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the bla KPC-2 gene was harbored by Tn 4401b transposons on two highly similar IncN plasmids.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02458-16

Authors: Brandon Eilertson, Liang Chen, Kalyan D. Chavda, Barry N. Kreiswirth

Institutions: State University of New York, SUNY Downstate Health Sciences University, Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: State University of New York, National Institute of Allergy and Infectious Diseases