Work

Absorbed radiation dosimetry of the D3-specific PET radioligand [18F]FluorTriopride estimated using rodent and nonhuman primate.

Year: 2016

Type: article

Abstract: F]FTP based on rat and primate data can be attributed to the slower transit of tracer through the hepatobiliary track of the primate compared to the rat, which lacks a gallbladder. Out findings demonstrate that the nonhuman primate model is more appropriate model for estimating human absorbed radiation dosimetry when hepatobiliary excretion plays a major role in radiotracer elimination.

Source: PubMed

Authors: Richard Laforest, Morvarid Karimi, Stephen M Moerlein, Jinbin Xu, Hubert P Flores, Christopher Bognar, Aixiao Li, Robert H Mach, Joel S Perlmutter, Zhude Tu

Institutions: Washington University in St. Louis, University of Pennsylvania

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Parkinson Disease Association, National Institutes of Health

OpenAlex ID: W2587053232

FWCI: 1.051

Cites: 20

Cited by: 7

Related to: 10