Cone Photoreceptor Structure and Function in Adolescents and Young Adults with Type 1 Diabetes
Year: 2014
Type: dissertation
Study design: Observational Study
Abstract: This cross-sectional study assessed properties of cone photoreceptors in patients with type 1 diabetes, as potential biomarkers of sub-clinical retinopathy. Patients with no vascular signs of retinopathy (ages 12-25) exhibited abnormal neuroretinal structure and function of the cone photoreceptor layer as compared to age-similar controls. White flash electroretinogram a-waves, demonstrating L- and M-cone function, were significantly less steep in patients than in controls (by 1.3 mV/ms, 95% CI: -0.3, -2.3, p=0.01). Red flash electroretinograms did not differ between groups. Adaptive optics retinal imaging was used to visualize L- and M-cones in vivo. At 7.1
Source: TSpace (University of Toronto)
Author: Elizabeth Laura Finkelberg
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2587329471