Redox Tuning of Flavin and Ultrafast Electron Transfer Mechanisms in DNA Repair by Photolyases
Year: 2016
Type: article
Abstract: Therefore, a new, unified electron-transfer strategy for all photolyases with bifurcated routes through the conserved bent FAD cofactor is proposed.With structural differences in FAD and substrate binding, the time scales of the elementary steps involved in repair differ greatly throughout the highly diversified photolyase family.Nevertheless, in all photolyases, the initial electron injection manifests a bifurcation of direct electron tunneling and two-step electron hopping.Both pathways are operative in CPD repair with divergent efficiencies depending on distinct reduction potentials in different protein environment, and are converged at active site for efficient repair.From lower microbes to higher eukaryotes, the electron exploits from mainly direct tunneling along one route to dominant two-step hopping on the other path with the same conserved active-site structure through evolution, to maintain decent repair efficiency and thus genome stability.v Dedicated to my family.
Author: Meng Zhang
Institution: The Ohio State University
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2587557543