Year: 2017
Type: review
Abstract: The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions. Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity during embryogenesis and in various diseases.
Source: Nature Communications
DOI: 10.1038/ncomms14361
Institutions: Uppsala University, IFOM, Yale University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Funders: Connecticut Innovations, Yale University, European Commission, Fondazione Cariplo, Associazione Italiana per la Ricerca sul Cancro, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences, FP7 Ideas: European Research Council
Awards: G1119858749, G1513917873, Transcriptional regulation of endothelial blood brain barrier differentiation by Wnt signaling, Multi-tissue platform for modeling systemic pathologies, G4017343059, Neurovascular Regeneration, Integrated heart-liver-vascular systems for drug testing in human health and dise, Angiogenesis and Ischemia, Integrated heart-liver-vascular systems for drug testing in human health and dise, Human Endothelial Cell Differentiation, Brain barriers training, Molecular Mechanisms of Arterigenesis, Specification of Hemogenic Endothelial Cells, Junctional adhesion molecule-a: a new key regulator for colorectal cancer, G9000082847, Yale Clinical and Translational Science Award
OpenAlex ID: W2587625705