Work

Inside Cover: In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation (Angew. Chem. Int. Ed. 8/2017)

Year: 2017

Type: article

Abstract: Nitrobenzothiazinones are highly potent antibiotics against Mycobacterium tuberculosis. While their killing mechanism involves the reduction of the nitro to a reactive nitroso group, F. Kloss and co-workers describe in their Communication on page 2187 ff. a previously overlooked in vivo bioreduction pathway. The metabolites are transient hydride Meisenheimer complexes that are readily reoxidized under atmospheric conditions and completely unprecedented among drug metabolites.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201700069

Authors: Florian Kloss, Viktor Krchnak, Anna Krchnakova, Sebastian Schieferdecker, Julia Dreisbach, Volker Krone, Ute Möllmann, Michael Hoelscher, Marvin J. Miller

Institutions: Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI), BioControl Jena (Germany), University of Notre Dame, Palacký University Olomouc, German Center for Infection Research, Ludwig-Maximilians-Universität München

Language: English

Topic: Phenothiazines and Benzothiazines Synthesis and Activities

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2587675456

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