Work

Metabolic Consequences of Restorative Surgery After Gastric Bypass

Year: 2017

Type: article

Abstract: Roux-en-Y gastric bypass (RYGB) improves the metabolic profile of patients with type 2 diabetes mellitus (T2DM). Surgical weight loss can improve insulin sensitivity and β-cell function. Furthermore, there is a growing body of evidence explaining improvement of T2DM after bariatric surgery by weight-independent neurohormonal mechanisms, including changes in gut hormones, bile acids, and gut microbiota. Changes to gastrointestinal anatomy (for example, exclusion of the duodenum in RYGB) can directly influence glucose homeostasis, independent of weight loss (1–3). Bariatric and metabolic surgery is not without some risk, though, and reoperation is sometimes necessary to manage long-term complications. Metabolic consequences of reoperative bariatric procedures have not been well characterized (4,5). The aim of this report is to present examples of how reoperative surgery can impact the metabolic effects of these operations. The first patient was a 47-year-old woman with a BMI of 38 kg/m2. She had a history of T2DM …

Source: Diabetes Care

DOI: 10.2337/dc16-2561

Authors: Ali Aminian, Stacy A. Brethauer, Neha Parekh, Kareem M. Abu-Elmagd, Philip R. Schauer

Institution: Cleveland Clinic

Language: English

Topic: Bariatric Surgery and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2587687622