Meta-Analyses of Microarray Data Reveals Interferon Signaling Is Top Canonical Pathway in Human Immunodeficiency Virus (HIV)
Year: 2015
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Background. Although many different studies have profiled gene expression for humans in response to HIV, most have been performed by only a single group or laboratory and suffer from a lack of generalizability of their results. Methods. In this work, we define robust gene signatures or specific patterns of gene expression for the human response to HIV phenotypes through two different meta-analyses. The first is a disease signature found in PBMCs for HIV versus control patients that consists of 24 series. The second is a signature in PBMCs for patients with an elite response to HIV versus patients with a standard response that consists of 5 series. Results. We have found interferon signaling to be the top canonical pathway with IFNA2 to be the top upstream regulator in HIV. We have also found that Myd88 is upregulated in HIV, but is not as upregulated in patients with an elite response. Related to this, we've found that TLRs 1, 2, 3, and 8 are all upregulated while TLRs 9 and 10 are downregulated in HIV and TLR5 and TLR7 are both expressed less in elite responders. Conclusion. Interferon has long been suspected as a potential treatment for HIV-infected patients, and our work support this hypothesis. The robust gene signatures we report here are a first step towards novel transitional opportunities for better biomarkers and drugs for the disease. Disclosures. All authors: No reported disclosures.
Source: Open Forum Infectious Diseases
Authors: Osama El-Sayed, Omar Hadied, Jihad Al-Jabban, Bilal Zaidi, Shuaib Raza, James Pan, Tej Azad, Imad Al-Jabban, Dexter Hadley
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W2587697434