SP-0506: New radiobiology for severe/extreme hypo: abandoning the LQ model or integrating it ?
Year: 2015
Type: conference-abstract
Abstract: In radiosurgery or stereotactic radiotherapy geometric inaccuracies are present throughout the treatment chain.Besides setup variability and intrafraction motion, geometric imperfections in treatment preparation, planning and dose delivery become relevant in stereotactic treatment.Their impact depends on the type of error (e.g.grand mean, systematic, random) and on technological treatment characteristics.Current perspectives on the management of these geometric uncertainties range between two extremes: the radiosurgery perspective (single fraction, ablative dose, no margins) and the radiotherapy perspective (hypo-fractionated, high dose, PTV/PRV margin).Various combinations of and adaptations on these perspectives are described in the literature.Additional considerations that influence the management of geometric uncertainties include: disease site, tumor type, treatment intent, treatment risk, radiobiology, clinical experience etc.In practice, the ways in which geometric uncertainties are accounted for vary per institute, per tumor (group) and even per patient; partly because of actual differences in geometric treatment characteristics and partly as a result of different views.Consistent management of geometric uncertainties within and across institutes is important for 1. establishing accurate dose-effect relations, 2. an unambiguous relationship between technology advancement and margin reduction or dose prescription for optimal treatment.Therefore, a unified perspective on geometric accuracy (with)in radiosurgery and stereotactic radiotherapy is warranted.By reviewing and comparing the different views, management and nature of geometric uncertainties in the chains of radiosurgery and stereotactic radiotherapy, we aim to contribute to such a unified perspective.
Source: Radiotherapy and Oncology
Author: M.C. Joiner
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,770
OpenAlex ID: W2587877552