Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: Network meta-analysis
Year: 2017
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Background Few trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies. Aims To combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA). Method Systematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF). Results Carer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive–behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores. Conclusions Only interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication non-adherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
Authors: Mary Lou Chatterton, Emily Stockings, Michael Berk, Jan J. Barendregt, Rob Carter, Cathrine Mihalopoulos
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Evidence-based Mental Health Planning: Translating Evidence into Policy and Services, Externalising behaviours in young people: predictors, prevention and treatment., Cost-Effectiveness in Australian Mental Health Services: Improving the evidence and relevance to decision-makers., Novel therapies, risk pathways and prevention of mood disorders
OpenAlex ID: W2588065774