Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Year: 2017
Type: article
Abstract: , thereby promoting self-ubiquitination and less ubiquitination and subsequent degradation of p53, thus increasing p53-dependent apoptosis. Therefore, this study indicates that dynamic acetylation is a molecular switch in the regulation of MDM2 substrate specificity, revealing further insight into the posttranslational regulation of the MDM2/p53 cell survival axis.
Source: Science Signaling
Authors: Naoe T. Nihira, Kohei Ogura, Kouhei Shimizu, Brian J. North, Jinfang Zhang, Daming Gao, Hiroyuki Inuzuka, Wenyi Wei
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Modulation of lipid homeostasis in maintenance and directed differentiation of mesenchymal stem cells, G1955427308, Mechanisms Controlling BubR1 Regulation of Cancer and Aging, G2833937372, New insights into the role of the Fbw7 tumor suppressor in senescence and aging, Characterizing the signaling pathways that regulate Skp2 oncogenic function, Novel regulation of PI3K/Akt to direct targeted breast cancer therapies, Functional analysis of beta-TRCP in cell cycle control and DNA damage response, Interplay between Cdh1 and major regulatory pathways in human cancer, Identification of proteolytic signaling pathways regulating reprogramming during iPS cell generation, Adipose insulin signaling regulated by brain KATP channel, Targeting the APC/Cdc20 E3 ubiquitin ligase for chemoradiation sensitization, G8503400498
OpenAlex ID: W2588201113