Work

Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise

Year: 2017

Type: review

Abstract: Biomarker development in lupus nephritis (LN) has traditionally relied on comparing the characteristics of candidate markers to clinical findings in patients and controls from cross-sectional cohorts. In this work, two additional strategies for LN biomarker development that are gaining ground will be discussed. One approach compares analytes directly to kidney histology. The second strategy utilizes longitudinal measurements of biomarker levels at regular intervals as patients move from disease quiescence to disease flare. These approaches have begun to empower biomarkers as diagnostic and prognostic tools in LN and have revealed novel and sometimes unexpected roles for these biomarkers in the pathogenesis and prediction of LN disease activity.

Source: Nephrology Dialysis Transplantation

DOI: 10.1093/ndt/gfw300

Authors: Daniel J Birmingham, Michael Merchant, Sushrut S Waikar, Haikady Nagaraja, Jon B Klein, Brad H Rovin

Institutions: The Ohio State University Wexner Medical Center, The Ohio State University, University of Louisville, Brigham and Women's Hospital

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources