LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer.
Year: 2016
Type: article
Abstract: Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen deprivation therapy (ADT) to have a better effect to fight against PCa, especially castration-resistant prostate cancer (CRPC). This review would systematically summarize the multicellular events controlled by ncRNAs and give a snapshot of future scientific activities and clinical applications.
Source: PubMed Central
Authors: Guoxing Ma, Mingqing Tang, Yaqing Wu, Xiaoming Xu, Feng Pan, Ruian Xu
Institution: Huaqiao University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2588334176