Evaluation of platelet indices in Acute Coronary Syndromes and Diabetes Mellitus.
Year: 2017
Type: article
Study design: Observational Study
Abstract: Background: Acute Coronary Syndrome (ACS) is the most common cause of adult mortality worldwide. Atheromatous plaque with superimposed thrombus is the commonest underlying cause. Platelets play a pivotal role initiating a thrombus, larger platelets being metabolically more active than the smaller ones. Hence the aim is to study the changes in platelet volume indices and platelet count in acute coronary syndromes and diabetes mellitus. Methods: This was a comparative study of 120 people (60 controls, 60 with ACS).ACS patients were subdivided as those with and without diabetes. Blood was collected in EDTA anticoagulated tubes.The platelet indices and platelet count were assayed using 8 part hematology analyzer (HORIBA) and compared among the groups. Result: Mean platelet volume (MPV) and platelet distribution width (PDW) were significantly raised in ACS patients, being higher in ST elevation Myocardial infarction(STEMI) followed by Non-ST elevation Myocardial infarction( NSTEMI), unstable angina(UA) and controls. The mean values of MPV and PDW were 8.86fl and 15.24% in STEMI, 8.76fl and 14.62% in NSTEMI, 8.17fl and 13.54% in UA, 8.04fL and 12.74% in controls respectively. Plateletcrit and platelet count did not show significant variation among the groups. Both MPV and PDW were higher in diabetic ACS patients (8.66 fl and 15.71% ) than the non-diabetics(8.17 fl and 14.2% ). Conclusion: Patients with acute coronary syndromes and diabetes had higher MPV and PDW compared to the controls. Measurements of platelet volume indices may be of some benefit in detecting those patients at higher risk for acute coronary events.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2588339507