Work

Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

Year: 2017

Type: article

Abstract: In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.

Source: Interface Focus

DOI: 10.1098/rsfs.2016.0104

Authors: Alexander Galkin, Salvador Moncada

Institutions: Queen's University Belfast, Weill Cornell Medicine, University of Manchester, Cancer Research UK Manchester Centre

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Medical Research Council